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Muramatsu, Takashi; Masuda, Shinichiro; Kotoku, Nozomi; Kozuma, Ken; Kawashima, Hideyuki; Ishibashi, Yuki; Nakazawa, Gaku; Takahashi, Kuniaki; Okamura, Takayuki; Miyazaki, Yosuke; Tateishi, Hiroki; Nakamura, Masato; Kogame, Norihiro; Asano, Taku; Nakatani, Shimpei; Morino, Yoshihiro; Katagiri, Yuki; Ninomiya, Kai; Kageyama, Shigetaka; Takahashi, Hiroshi; Garg, Scot; Tu, Shengxian; Tanabe, Kengo; Ozaki, Yukio; Serruys, Patrick W.; Onuma, Yoshinobu
Circulation Journal, 05/2023, Volume: 87, Issue: 6Journal Article
Background: P2Y12 inhibitor monotherapy without aspirin immediately after percutaneous coronary intervention (PCI) has not been tested in East Asian patients, so in this study we aimed to assess the safety and feasibility of reduced dose (3.75 mg/day) prasugrel monotherapy in Japanese patients presenting with chronic coronary syndrome (CCS).Methods and Results: ASET-JAPAN is a prospective, multicenter, single-arm pilot study that completed enrolment of 206 patients from 12 Japanese centers in September 2022. Patients with native de-novo coronary lesions and a SYNTAX score <23 were treated exclusively with biodegradable-polymer platinum-chromium everolimus-eluting stent(s). Patients were loaded with standard dual antiplatelet therapy (DAPT) and following successful PCI and optimal stent deployment, they received low-dose prasugrel (3.75 mg/day) monotherapy for 3 months. The primary ischemic endpoint was a composite of cardiac death, spontaneous target-vessel myocardial infarction, or definite stent thrombosis. The primary bleeding endpoint was Bleeding Academic Research Consortium (BARC) type 3 or 5. At 3-month follow-up, there were no primary bleeding or ischemic events, or any stent thrombosis.Conclusions: This pilot study showed the safety and feasibility of prasugrel monotherapy in selected low-risk Japanese patients with CCS. This “aspirin-free” strategy may be a safe alternative to traditional DAPT following PCI.
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