Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity

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Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity

Huong, Pham Thi Mai; Phong, Nguyen Viet; Huong, Nguyen Thi; Trang, Duong Thu; Thao, Do Thi; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Van Thanh, Nguyen

Journal of natural medicines, 2022/1, Volume: 76, Issue: 1

Journal Article

Aplydactylonins A-C ( 1 – 3 ), three new sesquiterpenes, were isolated from the Vietnamese sea hare Aplysia dactylomela . Their structures and absolute configurations were elucidated based on spectroscopic analysis, X-ray crystallography, and density functional theory (DFT) calculations of NMR and ECD data. Compound 2 exhibited cytotoxicity against HepG2, DU145 and A549 cells with respective IC 50 values of 4.08 ± 0.63, 38.64 ± 1.04 and 12.33 ± 0.95 µM. In addition, HepG2 cells treated with 5 μM compound 2 for 48 h showed a significant increase in early apoptotic cells ( P < 0.05) and increased caspase 3 activity ( P < 0.01). Moreover, compound 2 induced sub-G1 phase arrest in HepG2 cells.

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