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Hu, Bin-bin; Wang, Xiao-yan; Gu, Xu-Yu; Zou, Chen; Gao, Zhen-jun; Zhang, Heng; Fan, Yu
Molecular cancer, 12/2019, Volume: 18, Issue: 1Journal Article
Abstract Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m 6 A methylation has attracted increasing research interest in recent years. m 6 A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m 6 A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m 6 A in gastrointestinal tract cancers.
