Mortality, seasonal variation, and susceptibility to acute exacerbation of COPD in the pandemic year : a nationwide population studyŠarc, Irena ...Background: Previous studies have suggested that the coronavirus disease 2019 (COVID-19) pandemic was associated with a decreased rate of acute exacerbation of chronic obstructive pulmonary disease ... (AECOPD). Data on how the COVID-19 pandemic has influenced mortality, seasonality of, and susceptibility to AECOPD in the chronic obstructive pulmonary disease (COPD) population is scarce. Methods: We conducted a national population-based retrospective study using data from the Health Insurance Institute of Slovenia from 2015 to February 2021, with 2015–2019 as the reference. We extracted patient and healthcare data for AECOPD, dividing AECOPD into severe, resulting in hospitalisation, and moderate, requiring outpatient care. The national COPD population was generated based on dispensed prescriptions of inhalation therapies, and moderate AECOPD events were analysed based on dispensed AECOPD medications. We extracted data on all-cause and non-COVID mortality. Results: The numbers of severe and moderate AECOPD were reduced by 48% and 34%, respectively, in 2020. In the pandemic year, the seasonality of AECOPD was reversed, with a 1.5-fold higher number of severe AECOPD in summer compared to winter. The proportion of frequent exacerbators (2 AECOPD hospitalisations per year) was reduced by 9% in 2020, with a 30% reduction in repeated severe AECOPD in frequent exacerbators and a 34% reduction in persistent frequent exacerbators (2 AECOPD hospitalisations per year for 2 consecutive years) from 2019. The risk of two or more moderate AECOPD decreased by 43% in 2020. In the multivariate model, pandemic year follow-up was the only independent factor associated with a decreased risk for severe AECOPD (hazard ratio [HR]: 0.71; 95% confidence interval [CI]: 0.61–0.84; p < 0.0001). In 2020, non-COVID mortality decreased (−15%) and no excessive mortality was observed in the COPD population. Conclusion: In the pandemic year, we found decreased susceptibility to AECOPD across severity spectrum of COPD, reversed seasonal distribution of severe AECOPD and decreased non-COVID mortality in the COPD population.Vir: Therapeutic advances in respiratory disease. - ISSN 1753-4658 (Vol. 16, Jan./Dec. 2022, str. 1-15)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2022Jezik - angleškiCOBISS.SI-ID - 100243459
Pulmonary disease, chronic obstructive | Mortality | Pandemics | Seasons | Kronična obstruktivna pljučna bolezen | Umrljivost | Pandemije | Letni časi | exacerbation | acute exacerbation | seasonal variations | population study | poslabšanje | akutno poslabšanje | sezonska nihanja | populacijska raziskava
Vnos na polico
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Baze podatkov, v katerih je revija indeksirana
|Ime baze podatkov||Področje||Leto|
|Povezave do osebnih bibliografij avtorjev||Povezave do podatkov o raziskovalcih v sistemu SICRIS|
|Lotrič Dolinar, Aleša||19763|
|Rozman, Aleš, 1973-||25177|
|Došenović Bonča, Petra||23012|
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