-
The influence of heterochronic non-myeloablative bone marrow transplantation on the immune system, frailty, general health, and longevity of aged murine recipients [Elektronski vir]Jazbec, Katerina ...The stem cell theory of aging postulates that stem cells become inefficient at maintaining the original functions of the tissues. We, therefore, hypothesized that transplanting young bone marrow (BM) ... to old recipients would lead to rejuvenating effects on immunity, followed by improved general health, decreased frailty, and possibly life span extension. We developed a murine model of non-myeloablative heterochronic BM transplantation in which old female BALB/c mice at 14, 16, and 18(19) months of age received altogether 125.1 ± 15.6 million nucleated BM cells from young male donors aged 7–13 weeks. At 21 months, donor chimerism was determined, and the immune system’s innate and adaptive arms were analyzed. Mice were then observed for general health and frailty until spontaneous death, when their lifespan, post-mortem examinations, and histopathological changes were recorded. The results showed that the old mice developed on average 18.7 ± 9.6% donor chimerism in the BM and showed certain improvements in their innate and adaptive arms of the immune system, such as favorable counts of neutrophils in the spleen and BM, central memory Th cells, effector/effector memory Th and Tc cells in the spleen, and B1a and B1b cells in the peritoneal cavity. Borderline enhanced lymphocyte proliferation capacity was also seen. The frailty parameters, pathomorphological results, and life spans did not differ significantly in the transplanted vs. control group of mice. In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects.Vir: Biomolecules [Elektronski vir]. - ISSN 2218-273X (Vol. 12, iss. 4, 2022, str. [1]-21)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2022Jezik - angleškiCOBISS.SI-ID - 105264643
Avtor
Jazbec, Katerina |
Jež, Mojca, 1985- |
Švajger, Urban |
Smrekar, Boštjan, biokemik |
Miceska, Simona |
Rajčević, Uroš |
Justin, Mojca |
Završnik, Janja |
Malovrh, Tadej |
Švara, Tanja |
Gombač, Mitja |
Ramšak, Živa, 1985- |
Rožman, Primož, 1954-
Teme
bone marrow transplantation |
immune system |
aging |
presaditev kostnega mozga |
imunski sistem |
staranje
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Jazbec, Katerina | 38276 |
Jež, Mojca, 1985- | 30968 |
Švajger, Urban | 26198 |
Smrekar, Boštjan, biokemik | 29086 |
Miceska, Simona | 51443 |
Rajčević, Uroš | 20345 |
Justin, Mojca | 50621 |
Završnik, Janja | 34458 |
Malovrh, Tadej | 16346 |
Švara, Tanja | 18884 |
Gombač, Mitja | 17569 |
Ramšak, Živa, 1985- | 34502 |
Rožman, Primož, 1954- | 12336 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.