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  • Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
    Onyango, Isaac G. ...
    Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with ... multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.
    Vir: Neural Regeneration Research. - ISSN 1673-5374 (Vol. 16, is.8, Aug. 2021, str. 1467-1482)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 107084035

    Povezava(-e):

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323696/pdf/NRR-16-1467.pdf
    DOI

vir: Neural Regeneration Research. - ISSN 1673-5374 (Vol. 16, is.8, Aug. 2021, str. 1467-1482)
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