-
In situ monitoring of electric field distribution in mouse tumor during electroporationKranjc, Matej, 1983- ...To investigate the feasibility of magnetic resonance (MR) electric impedance tomography (EIT) technique for in situ monitoring of electric field distribution during in vivo electroporation of mouse ... tumors to predict reversibly electroporated tumor areas. Materials and Methods All experiments received institutional animal care and use committee approval. Group 1 consisted of eight tumors that were used for determination of predicted area of reversibly electroporated tumor cells with MR EIT by using a 2.35-T MR imager. In addition, T1-weighted images of tumors were acquired to determine entrapment of contrast agent within the reversibly electroporated area. A correlation between predicted reversible electroporated tumor areas as determined with MR EIT and areas of entrapped MR contrast agent was evaluated to verify the accuracy of the prediction. Group 2 consisted of seven tumors that were used for validation of radiologic imaging with histopathologic staining. Histologic analysis results were then compared with predicted reversible electroporated tumor areas from group 1. Results were analyzed with Pearson correlation analysis and one-way analysis of variance. Results Mean coverage % standard deviation of tumors with electric field that leads to reversible electroporation of tumor cells obtained with MR EIT (38% % 9) and mean fraction of tumors with entrapped MR contrast agent (41% % 13) were correlated (Pearson analysis, r = 0.956, P = .005) and were not statistically different (analysis of variance, P = .11) from mean fraction of tumors from group 2 with entrapped fluorescent dye (39% % 12). Conclusion MR EIT can be used for determining electric field distribution in situ during electroporation of tissue. Implementation of MR EIT in electroporation-based applications, such as electrochemotherapy and irreversible electroporation tissue ablation, would enable corrective interventions before the end of the procedure and would additionally improve the treatment outcome.Vir: Radiology. - ISSN 0033-8419 (Vol. 274, iss. 1, Jan. 2015, str. 115-123)Vrsta gradiva - članek, sestavni delLeto - 2015Jezik - angleškiCOBISS.SI-ID - 10729556
Avtor
Kranjc, Matej, 1983- |
Markelc, Boštjan |
Bajd, Franci |
Čemažar, Maja |
Serša, Igor |
Blagus, Tanja |
Miklavčič, Damijan
Teme
elektroporacija |
slikanje z magnetno resonanco |
magnetnoresonančna električnoimpedančna tomografija |
električno polje |
electroporation |
magnetic resonance imaging |
magnetic resonance electrical impedance tomography |
electric field
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Kranjc, Matej, 1983- | 29553 |
Markelc, Boštjan | 32175 |
Bajd, Franci | 30867 |
Čemažar, Maja | 14575 |
Serša, Igor | 12056 |
Blagus, Tanja | 34769 |
Miklavčič, Damijan | 10268 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.