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  • Value of F-18-FDG PET in patients with cervical lymph node metastases of unknown origin = Pomen preiskave s F-18-FDG PET pri bolnikih z mestazami v vratnih bezgavkah neznanega izvora
    Bohuslavizki, Karl H. ...
    Background. Cancer of unknown primary is still a major diagnostic problem in patients with lymph node metastases despite a large variety of imaging modalities. Therefore, the aim of this study was to ... evaluate the impact of F-18-FDG positron emission tomography (PET) in these patients. Materials and methods. A total of 28 patients aged 39 to 84 years with cervical lymph node metastases of squamous cell carcinoma (n=24) or an undifferentiated carcinoma (n=4) were investigated. Prior to PET a complete history, physical examination, ultrasound of the neck, panendoscopy, and CT of the head and neckregion were performed in all patients without detection of the primary tumour site. All patients received 370 MBq F-18-FDG intravenously, and whole-body images were acquired at 60 min p.i. using an ECAT EXACT 47 (921) (Siemens, CTI). All lesions were evaluated either by histology or by subsequent CT/MRL Results. In 16/28 patients PET showed focal tracer accumulations corresponding to potential primary tumour sites located in the lungs (n=7), in the region of the palatine tonsil (n=5), the submandibular gland (n=1), the nasopharynx (n=1), the larynx (n=1), and at the base of the tongue (n=1). In 9 out of tlsese 16 patients the primary tumour could be confirmed in the lungs (n=5), in the larynx, at the base of the tongue, the nasopharynx and the palatine tonsil in one patient each, respectively. In 6/16patients PET lesions were false positive, predominantly located in the palatine tonsil (n=3). One patient denied further evaluation of PET findings. However, in 12/28 patients PET did not reveal tumour-suspicious lesions. Conclusions. Since F-18-FDG PET detected the primary tumour site in approximately one third of the patients with cervical node metastases from an unknown primary (CUP-syndrome), F-18-FDG PET is a valuable diagnostic tool which might help to select a potentially curative treatment protocol in these patients.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Letn. 33, št. 3, 1999, str. 207-213)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - angleški
    COBISS.SI-ID - 10781401

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

vir: Radiology and oncology. - ISSN 1318-2099 (Letn. 33, št. 3, 1999, str. 207-213)
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