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Ribociclib plus letrozole in patients with hormone receptor-positive, HER2-negative advanced breast cancer with no prior endocrine therapy : subgroup safety analysis from the phase 3b CompLEEment-1 trialBorštnar, Simona, 1967- ...The CDK4/6 inhibitor, ribociclib in combination with endocrine therapy significantly improved progression-free survival in the first line setting in post-menopausal patients with HR+/HER2- advanced ... breast cancer (ABC) in a pivotal phase 3, placebo-controlled trial (MONALEESA-2) and demonstrated superior overall survival in premenopausal patients with HR+/HER2- ABC (MONALEESA-7). The multinational, phase 3b, CompLEEment-1 trial, which assessed the safety and efficacy of ribociclib plus letrozole in a broader population of patients who have not received prior endocrine therapy for advanced disease, is the largest phase 3 clinical trial to date to evaluate the safety and efficacy of a CDK4/6 inhibitor. We report a subanalysis of data from patients (N = 339) enrolled in the central and south European countries of the SERCE (Southern Europe, RUC, Central Europe) cluster of CompLEEment-1. Patients and methods: Men and women of any menopausal status with HR+/HER2- ABC received once-daily oral ribociclib 600 mg (3-weeks on/1-week-off), plus letrozole 2.5 mg continuously. Men/premenopausal women also received a GnRH-agonist. The primary outcome was the number of patients with adverse events (AEs) over a timeframe of approximately 36 months. Time-to-progression, overall response rate, and clinical benefit rate were also measured. Results: Safety results in the SERCE subgroup were consistent with those in the pivotal clinical trials of ribociclib in combination with endocrine therapy. Treatment-related AEs leading to dose adjustments/interruption occurred in 63.1% of patients but led to treatment discontinuation in only 10.6%. The most common treatment-related AEs of grade ≥ 3 were neutropenia and transaminase elevations. There were no fatal treatment-related events. Conclusions: These findings from the SERCE subgroup support the safety and manageable tolerability of ribociclib in a broad range of patients with HR+/HER2- ABC more representative of patients in real-world clinical practice.Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 56, no. 2, 2022, str. 238-247)Vrsta gradiva - članek, sestavni delLeto - 2022Jezik - angleškiCOBISS.SI-ID - 108184835
Avtor
Borštnar, Simona, 1967- |
Palacova, Marketa |
Łacko, Aleksandra |
Timcheva, Constanta |
Gal-Yam, Einav Nili |
Papazisis, Konstantinos |
Beniak, Juraj |
Kudela, Pavol |
Rubovszky, Gábor
Teme
CDK4/6 inhibitor |
HER2− |
HR+ |
advanced breast cancer |
ribociclib |
inhibitor CDK4/6 |
HER2− |
HR+ |
napredovali rak dojke |
ribociclib
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Borštnar, Simona, 1967- | 16303 |
Palacova, Marketa | ![]() |
Łacko, Aleksandra | ![]() |
Timcheva, Constanta | ![]() |
Gal-Yam, Einav Nili | ![]() |
Papazisis, Konstantinos | ![]() |
Beniak, Juraj | ![]() |
Kudela, Pavol | ![]() |
Rubovszky, Gábor | ![]() |
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