VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Quantitative trait loci affecting growth in high growth (hg) mice
    Corva, Pablo M. ; Horvat, Simon ; Medrano, Juan F.
    A genome-wide scan performed in order to identify Quantitative Trait Loci (QTL) associated with growth in a population segregating high growth (hg), a partially recessive mutation that enhances ... growth rate and body size in the mouse. A sample of 262 hg/hg mice was selected from C57BL/6J-hg/hg x CAST/EiJ F[down]2 cross and typed with 79 SSLP markers distributed across the genome. Eight significant loci were identified through interval mapping. Loci on Chromosomes (CHRS) 2 and 8 affected the growth of F [down]2 mice. Loci on Chr 2 and 11 affected growth rate and carcass lean mass (protein and ash). A locus on Chr 9 modified femur length and another one in Chr 17 affcted both carcass lean mass and femur length, but none of these had significant effects on growth rate. Loci on Chrs 5 and 9 modified carcass fat content. Additive effects were positive for C5BL/6J alleles, except for the two loci affecting carcass fatness. Typing of selelcted markers in 274 +/+F[down]2 mice revealed significant interactions between hg and other growth QTL, which were detected as changes in gene action (additive or dominant) and in allele substitution effects. Knowledge about interactions between loci, especially when major genes are involved, will help in the identification of positional candidate genes in the understanding of the complex genetic regulation of growth rate and body size in mammals.
    Vir: Mammalian genome. - ISSN 0938-8990 (Vol. 12, 2001, str. 284-290)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - angleški
    COBISS.SI-ID - 1113736

vir: Mammalian genome. - ISSN 0938-8990 (Vol. 12, 2001, str. 284-290)
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