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  • Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors [Elektronski vir]
    van Klaveren, Sjors ...
    Galectins are galactoside-binding proteins that play a role in various pathophysiological conditions, making them attractive targets in drug discovery. We have designed and synthesised a focused ... library of aromatic 3-triazolyl-1-thiogalactosides targeting their core site for binding of galactose and a subsite on its non-reducing side. Evaluation of their binding affinities for galectin-1, -3, and -8N identified acetamide-based compound 36 as a suitable compound for further affinity enhancement by adding groups at the reducing side of the galactose. Synthesis of its dichlorothiophenyl analogue 59 and the thiodigalactoside analogue 62 yielded promising pan-galectin inhibitors.
    Vir: RSC advances [Elektronski vir]. - ISSN 2046-2069 (Vol. 12, iss. 29, 2022, str. 18973-18984)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 113857283

    Povezava(-e):

    https://pubs.rsc.org/en/content/articlelanding/2022/RA/D2RA03163A
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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