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  • Comparison of ADVIA Centaur ultra-sensitive and high-sensitive assays for troponin I in serum [Elektronski vir]
    Osredkar, Joško, 1955- ...
    Cardiac troponin I (cTnI) is a standard biomarker for the diagnosis of acute myocardial infarction (AMI). While older, ultra-sensitive cTnI (us-cTnI) assays use the 99th percentile as the reference ... threshold, newer high-sensitive cTnI (hs-cTnI) assays use the limit of detection or functional sensitivity instead. However, little has been done to systematically compare these two methods. The present study also served as a validation of hs-cTnI in our laboratory. Here, we compared the results obtained from the blood serum obtained from 8810 patients using the us-cTnI and the hs-cTnI assays run in tandem on the ADVIA Centaur XP analyser. We found that in 2279 samples the concentration of cTnI measured with the ultra-sensitive method was below the detection limit, while with the high-sensitive method, only 540 were below the detection limit. We also compared results from these assays with the ultimate diagnosis of a subset of individuals. The analysis of the results below cut-off with the ultra-sensitive method showed that this method would not detect 96 cases related to heart disorder. Overall, the main finding of our research is that hs-cTnI is the preferable option and is able to be deployed effectively in the laboratory setting.
    Vir: Practical laboratory medicine. - ISSN 2352-5517 (Vol. 33, art. e00293, 2022, str. 1-6)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 115290371

    Povezava(-e):

    https://www.sciencedirect.com/science/article/pii/S2352551722000324?via%3Dihub
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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