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  • Uporaba streptokinaze pri bolnikih z akutnim infarktom srca v Splošni bolnišnici Maribor = Streptokinase in treatment of patients with acute myocardial infarction in General hospital Maribor
    Sinkovič, Andreja
    Introduction. Acute myocardial infarction (AMI) is most important manifestation of coronary heart disease, which is still the leading cause of death in civilised world. Occlusive coronary thrombus at ... the site of atherosclerotic plaque is responsible for AMI in 90% of cases. The earlier itsdissolution by fibrinolytic agents, including streptokinase (STK), more probable the reperfusion of jeopardised myocardium, resulting in decreased mortality, decreased incidence of heart failure and sudden death after AMI. Materials and methods. Out of 340 patients with AMI, admitted during 23 months, 135 (39,6%) were treated with fibrinolytic agents: 104 patients (30,6%) with STK, the rest either with urokinase, or tissue-plasminogen-activator. 205 patients with AMI (60,2%) did not receive fibrinolytic therapy, because the inclusion criteria were not met (non-specific admission ECG and/or more than 12 hours from the start of chest pain) or major contraindications were present. The inclusion criteria for STK therapy were: (1) chest pain, lasting > 30 minutes, but < 12 hours, not responding to 2-3 sublingual nitroglicerin tablets; (2) ST-segment elevations for at least 1-2 mm in at least 2 leads of standard ECG; (3) major contraindications absent. After systemic intravenous infusion of STK, the outcome of treatment was assessed noninvasively. It was successful, when reperfusion was achieved without subsequent reinfarction and it failed, when reperfusion was delayed and/or reinfarction developed. Results. In 104 patients, treated with STK (78 men, 26 women, mean age 60,1 +- 11 years) mean time to therapy was 3,0 +- 2,3 hours (30 minutes - 12 hours), mean admission CK was 2,4 +- 3,3 ukat/L. 47 patients had anterior and 57 inferoposterior acute myocardial infarction. STK therapy was successful in 62,5% (65/104). It failed in 37,5% (39/104). In-hospital mortality was 9,6% (10/104), mainly due to heart failure. (Abstract truncated at 2000 characters).
    Vir: Urgentna medicina : izbrana poglavja 6 : zbornik = Emergency medicine : selected topics 6 : proceedings (Str. 305-312)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11649753

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