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  • Mnogojedrne velikanke v bronhoalveolarnih izpirkih = Multinucleated giant cells in bronchoalveolar lavage
    Kern, Izidor ...
    Background. Our knowledge about diagnostic significance and role of multinucleated giant cells (MGC) in the pathogenesis of lung diseases is limited. MGC are relatively common finding in cytological ... examination of bronchoalveolar lavage (BAL) specimens. The aim of this study was to ascertainthe frequency of MGC in BAL, possibility of MGC classification and the frequency of MGC finding in various lung diseases. Methods. Retrospectively we examined 527 BAL specimens. We defined MGC as cells larger than alveolar macrophages (AM) with one nucleus and having more than ten nuclei. From patients' files we collected data of bronchoscopic lung biopsy histology and final diagnosis of lung disease. BAL containing MGC were groupedin specimens of patients with sarcoidosis. interstitial lung diseases (ILD) and other chronic lung diseases. Results. We found MGC in 46 (8, 7%) BALspecimens. According to cytomorphological features MGC were classified in three types: Langhans or foreign-body type MGC, MGC resembling AM and undefined MGC. Langhans or foreign-body type MGC were significantly more oftenfound in BAL specimens of patients with sarcoidosis. MGC resembling AM were significantly more often found in BAL specimens of patients with other chronic lung diseases. Conclusions. We find MGC in rather small proportion of BAL specimens obtained from patients with various lung diseases. Cytomorphological features allow us to classify MGC in three different types. Data of MGC presence in BAL specimen can be useful together with other clinical in laboratory findings.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 7/8, julij-avgust 2000, str. 517-520)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11832537

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