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  • Current uncertainties and f... (naslovnica)
    Current uncertainties and future challenges regarding NAD+ boosting strategies [Elektronski vir]
    Poljšak, Borut, 1976- ; Kovač, Vito ; Milisav, Irina
    Precursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main boosters of NAD+. Increasing ... public awareness and interest in anti-ageing strategies and health-promoting lifestyles have grown the interest in the use of NAD+ boosters as dietary supplements, both in scientific circles and among the general population. Here, we discuss the current trends in NAD+ precursor usage as well as the uncertainties in dosage, timing, safety, and side effects. There are many unknowns regarding pharmacokinetics and pharmacodynamics, particularly bioavailability, metabolism, and tissue specificity of NAD+ boosters. Given the lack of long-term safety studies, there is a need for more clinical trials to determine the proper dose of NAD+ boosters and treatment duration for aging prevention and as disease therapy. Further research will also need to address the long-term consequences of increased NAD+ and the best approaches and combinations to increase NAD+ levels. The answers to the above questions will contribute to the more efficient and safer use of NAD+ boosters.
    Vir: Antioxidants [Elektronski vir]. - ISSN 2076-3921 (Vol. 11, iss. 9, 2022, str. 1-18)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 119104771

    Povezava(-e):

    https://www.mdpi.com/2076-3921/11/9/1637
    Repozitorij Univerze v Ljubljani – RUL
    DOI

Digitalne vsebine: dCOBISS

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