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Influence of the binder jetting process parameters and binder liquid composition on the relevant attributes of 3D-printed tablets [Elektronski vir]Kreft, Klemen ...Binder jetting has the potential to revolutionize the way we produce medicine. However, tablets produced by binder jetting technology can be quite fragile and hard to handle. In this study, the ... printing process and ink composition were examined to optimize the mechanical properties of tablets. A model formulation containing the ketoprofen drug was developed and used as a base for optimization. Firstly, important printing parameters were identified with a fractional factorial design. Saturation and layer height critically influenced selected tablet properties. Relevant process parameters were optimized for tablet mechanical strength by using the D-optimization DoE approach. The best mechanical properties were achieved when saturation was set to 1 and layer height to 150 µm. On the other hand, binder ink composition did not appear to impact tablet mechanical strength as much as process parameters did. Three ethanol-water mixtures were tested at three tablet strength levels and no definitive conclusions could be drawn. The binder jetting process can be wasteful, especially if the unbound powder cannot be reused. To determine the suitability of powder blend recycling, the ketoprofen content was measured for 27 subsequent batches of tablets. While the trendline did indicate a slight reduction in ketoprofen content, the powder blend reuse can nevertheless be employed.Vir: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 14, iss. 8, art. 1568, 2022, 21 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2022Jezik - angleškiCOBISS.SI-ID - 119609859
Avtor
Kreft, Klemen |
Lavrič, Zoran |
Stanić Ljubin, T. |
Perhavec, Petra, farmacevtka |
Dreu, Rok
Teme
Farmacevtska industrija |
Tablete |
brizganje veziva |
načrtovanje poskusov |
3D-natisnjene tablice |
mehanske lastnosti |
razvoj tiskalnikov |
ketoprofen |
binder jetting |
design of experiments |
3D-printed tablets |
mechanical properties |
printer development |
ketoprofen
Avtor | Kreft, Klemen ... |
Naslov | Influence of the binder jetting process parameters and binder liquid composition on the relevant attributes of 3D-printed tablets [Elektronski vir] |
Datum objave | 2022-07-28 |
COBISS.SI-ID | 119609859 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
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https://www.mdpi.com/1999-4923/14/8/1568 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=139091 |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kreft, Klemen | 54293 |
Lavrič, Zoran | 32037 |
Stanić Ljubin, T. | |
Perhavec, Petra, farmacevtka | |
Dreu, Rok | 21455 |
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