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  • Elevated troponin I level on admission is associated with adverse outcome of primary angioplasty in acute myocardial infarction
    Matetzky, Shlomo ...
    Background-In patients with acute myocardial infarction (AMI) undergoing thrombolytic therapy, an elevated troponin level on admission is associated with a lower reperfusion rate and a complicated ... clinical course. Whether an elevated troponin level on admission similarly predicts an adverse outcome in patients undergoing primary angioplasty is currently unknown and was investigated in the present study. Methods and Results-Cardiac troponin I (cTnI) was determined on admission in 110 consecutive patients with AMI associated with ST-segment elevation or left bundle branch block who underwentprimary angioplasty. Fifty-four patients (49%) had an elevated cTnI (>-0.4 ng/mL) on admission. In patients with elevated cTnI, primary angioptasty was less likely to achieve TIMI 3 flow (as classified by the Thrombolysis in Myocardial Infarction trial) in univariate (76% versus 96%, P=0.03) or in multivariate (odds ratio 0. 1, 95% CI 0.02 to 0.54) analysis. Patients with elevated cTnI were more likely to develop congestive heart failure (23% versus 9%, P<0.05) and death, heart failure, or shock (30% versus9%, P=0.006). Elevated cTnI remained a significant predictor of the composite end point after controlling for other clinical data that were available early in the course, including time to presentation and angiographicresults (relative risk 5.2, 95% CI 1.03 to 26.3). During a follow-up of 426+-50 days, elevated admission cTnI was a predictor of cardiac mortality (11% versus 0%, P=0.012), adverse cardiac events (cardiac mortality or nonfatal reinfarction; 19% versus 5.4%, P=0.04), and adverse cardiac eventsplus target vessel revascularization (32% versus 14%, P=0.054). Conclusions-In patients with ST-segment elevation AMI, an elevated cTnI on admission is associated with an increased risk of primary angioplasty failure and a more complicated clinical course.
    Vir: Circulation. - ISSN 0009-7322 (Letn. 102, 2000, str. 1611-1616)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 12345561

vir: Circulation. - ISSN 0009-7322 (Letn. 102, 2000, str. 1611-1616)
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