VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies [Elektronski vir]
    Proj, Matic ...
    For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity ... reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches to discover new viscosity-reducing agents: fingerprint similarity searching, and physicochemical property filtering. In total, 94 compounds were selected and experimentally evaluated on two model monoclonal antibodies, which led to the discovery of 44 new viscosity-reducing agents. Analysis of the results showed that using a simple filter that selects only compounds with three or more charge groups is a good ‘rule of thumb’ for selecting potential viscosity-reducing agents for two model monoclonal antibody formulations.
    Vir: Computational and Structural Biotechnology Journal [Elektronski vir]. - ISSN 2001-0370 (Vol. 20, 2022, str. 5420-5429)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 123845891

    Povezava(-e):

    https://www.sciencedirect.com/science/article/pii/S2001037022004408?via%3Dihub
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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