VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Cell cycle regulation proteins p21[sub]WAF1/CIP1 and p27[sub]KIP1 in squamous cell carcinoma of the larynx
    Cör, Andrej ...
    One of the main properties of cancer cells is their increased and deregulated proliferative activity. p21WAF1/CIP1 and p2Kip1 are members of the CIP/Kip family of cyclin dependent kinase inhibitor ... (CKI) proteins that negatively regulate cell proliferation. To improve our understanding of the role and clinical relevance of p21WAF1/CIP1 and p2Kip1 in squamous cell carcinoma (SCC)of the larynx, we analysed by immunohistochemistry p21WAF/CIP1 and p2Kip1expression in a series of 30 patients who had undergone laryngectomy dueto the laryngeal SCC. Proliferative activity was assessed in serial sectionby determining the expression of the cell cycle protein Ki-67. We founda statistically significant correlation between the grade of SCC and the percentage of Ki-67 positive cells (P<0.05). p21WAF1/CIP1 expression was strongly associated with squamous cell differentiation of carcinoma, because all seven carcinomas grade III showed very low levels of p21WAF1/CIP1 expression. No significant correlation between p21WAF1/CIP1 and Ki-67 was found. p27Kip protein was significantly reduced in carcinomas compared with that in normal epithelial controls. There was a negative correlation between the Ki-67 labelling index and p27Kip1 expression. In conclusion, this study has found that a reduction in the proportion of cells expressing p21WAF1/CIP1 and p27Kip1 protein is frequently associated with SCC of the larynx.
    Vir: Epithelial tumours of the head and neck : proceedings (Str. 149-152)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 12642265

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