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  • Epidemiologic, ecologic and clinical characteristics of Lyme borreliosis in northwest Croatia
    Golubić, Dragutin ...
    Investigated were the epidemiologic, ecologic and clinical characteristics of Lyme borreliosis in northwest Croatia. In a seroepidemiologic study, human sera were analyzed by indirect ... immunofluorescent assay (IFA), and ten out of 134 serum samples were positive for B. burgdorferi antibodies. In a seroepizootiologic study, wildlife and domestic animals were tested by inhibition ELISA. Antibodies to B. burgdorferi were found in nine out of 42 roe deer sera, and in three out of nine hare sera. Sera of wild boars (n =10),cattle (n =103), and dogs (n=113) were negative for antibodies to B. burgdorferi. The presence of Borrelia burgdorferi sensu lato was assessed in Ixodes ricinus ticks in the Lyme borreliosis endemic region of northwest Croatia. Ticks (n=123) were collected at five different locations and analyzedby polymerase chain reaction (PCR). Borrelia burgdorferi sensu lato DNA was detected in 56 out of 124 ticks (45%). Four genomic groups were identified by genotyping: B. afzeii (n=26), B. garnii (n=5), VS116 group (n=5), and Borrelia burgdorferi sensu stricto (n=1). Mixed infections of B. afzeii with VS116 group (n=10), and B. afzeii with Borrelia burgdorferi sensu stricto (n=1) were also detected. Eight ticks contained B. burgdorferi sensu lato that could not typed, indicating the possible existence of a sepcific genomic group of B. burgdorferi sensu lato in northwest Croatia. Sex distribution of Lyme borreliosis patients in northwest Croatia showed a slightpreponderance of the female gender and prevalence of the working active age range of 20 to 50 years.. The persons who periodically visit the landscape, are most commonly affected, whereas those with an increased risk oftick bites are considerably less frequently involved. The most frequent clinical manifestation of Lyme borreliosis in nortwest Croatia is erythema migrans with 46%, followed by neurologic manifestations, particularly peripheral neuritis, with 32%. (Abstract truncated at 2000 characters).
    Vir: Acta medica Croatica : časopis Hrvatske akademije medicinskih znanosti = the journal of the Croatian Academy of Medical Sciences. - ISSN 1330-0164 (Letn. 52, 1998, str. 7-13)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 12799961

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