VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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Vpliv hidrokortizona na sistemski arterijski tlak med kratkotrajno sistemsko infuzijo streptokinaze pri bolnikih z akutnim srčnomišičnim infarktom : magistrsko deloPernat, AndrejIn patients with acute myocardial infarction a transient fall in blood pressure frequently occurs during streptokinase (SK) infusion. This fall can depress efficacy of coronary thrombolysis induced ... by thrombolytic agents. The aim of our study was to evaluate whether treatment with hydrocortisone reducesfall in blood pressure (BP) during SK infusion in patients with acute myocardial infarction. We also wanted to identify subgroups of patients which would especially benefit from the effect of hydrocortisone, and to find out factors which affect BP during SK infusion. 182 patients with acute myocardialinfarction were included in a double blind, placebo controlled prospective study. A11 were treated with systemic infusion of SK. Half of themreceived 100 mg of hydrocortisone intravenously before the start of SK infusion, the other half received 2 ml of saline intravenously. Blood pressurewas measured twice before SK infusion, at the beginning of infusion and 5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 80, 100 and 120 minutes after the beginning of infusion. In patients who received hydrocortisone, the maximal fall in systolic BP during SK infusion was 18% lower than in patients who received placebo (28 +- 23 (SD) vs 34 +- 24 mm Hg, p=0.046). There were no significant differences in the maximal fall in mean and diastolic BP between the two groups. In the subgroup with systolic BP lower than 100 mm Hg the effect of hydrocortisone was even more pronounced. In patients who received hydrocortisone the maximal fall in systolic BP was 65% lower, the maximal fallin mean BP 40% lower, and the maximal fall in diastolic BP 29% lower than in the placebo group. However, the difference between the two groups is not significant. The only factor with a significant correlation with the lowest systolic BP during infusion was systolic BP before SK infusion. (Abstract truncated at 2000 characters)Vrsta gradiva - magistrsko deloZaložništvo in izdelava - Ljubljana : [A.Pernat], 1996Jezik - slovenskiCOBISS.SI-ID - 12804313
Avtor
Pernat, Andrej
Drugi avtorji
Horvat, Matija, 1935-2014 |
Pohar, Bojan, 1957-
Teme
Myocardial infarction |
Drug therapy |
Streptokinase |
Hydrocortisone |
Infusions, intravenous |
Blood pressure |
Thrombolytic therapy |
Hypotension |
Acute disease |
Time factors
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Pernat, Andrej | 14882 |
Horvat, Matija, 1935-2014 | 01531 |
Pohar, Bojan, 1957- | 03530 |
Vir: Osebne bibliografije
in: SICRIS
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