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Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstrictionVillaran, Cesar ...Background: Montelukast, a leukotriene receptor antagonist, and salmeterol, a long-acting (ß2-receptor agonist, each have demonstrated benefits in the treatment of exercise-induced ... bronchoconstriction (EIB) in short-term studies.Direct comparisons between these agents in long-term studies are limited. Objective: We sought to compare montelukast and salmeterol in the long-term treatment of EIB. Methods: One hundred ninety-seven patients with mild asthma and a postexercise fall in FEV, of at least 189 were randomized (double-blind) to receive montelukast 10 mg once daily or salmeterol 50 pg twice daily for 8 weeks. Exercise challenge was repeated at day 3, week 4, andweek 8 after randomization near the end of the dosing interval for both drugs. The primary efficacy endpoint was the maximal percent fall in postexercise FEVI at week 8. Results: Montelukast was effective in treating EIB without inducing tolerance and provided superior (PS .001) protection thansalmeterol at weeks 4 and 8, with comparable protection at day 3. The frequency of respiratory clinical adverse events (P = .046) and discontinuations because of clinical adverse events (P = .052) were less with montelukast. Conclusion: The effect of montelukast was greater than that of salmeterol in the chronic treatment of EIB over a period of 8 weeks in patients with mild asthma as demonstrated by effect size, maintenance of effect, and fewer respiratory clinical adverse events during the study period.Montelukast may be a better alternative to salmeterol as a controller agent for the chronic treatment of EIB.Vir: The Journal of allergy and clinical immunology. - ISSN 0091-6749 (Letn. 104, št. 3 Part 1, 1999, str. 547-553)Vrsta gradiva - članek, sestavni delLeto - 1999Jezik - angleškiCOBISS.SI-ID - 12860377
Avtor
Villaran, Cesar |
O'Neil, Shane J. |
Helbling, Arthut |
van Noord, Jan A. |
Lee, Tak H. |
Chuchalin, Alexander G. |
Langley, Stephen J. |
Gunawardena, Kulasiri A. |
Šuškovič, Stanislav |
Laurenzi, Martino |
Jasan, Jay |
Menten, Joris |
Leff, Jonathan A.
Teme
Asthma, exercise-induced |
Drug therapy |
Bronchoconstriction |
Drug effects |
Receptors, leukotriene |
Antagonists and inhibitors |
Adrenergic beta-agonists |
Forced expiratory volume |
Treatment outcome
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