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  • Expression of 17beta-hydroxysteroid dehydrogenases in mesophilic and extremophilic yeast
    Lanišnik-Rižner, Tea ; Adamski, Jerzy, molekularna biologija ; Žakelj-Mavrič, Marija
    17beta-hydroxysteroid dehydrogenases (17beta-HSDs) are enzymes responsible forreversible interconversions of biologically active 17-hydroxy and inactive 17-keto steroids. We have performed a survey ... of 17beta-HSD activity in yeast. Constitutive 17beta-HSD activity was found in three mesophilic yeast species: Candida tropicalis, Cryptococcus tsukubaensis, and Saccharomyces cerevisiae aswell as in three extremophilic black yeast species: Hortaea werneckii, Trimmatostroma salinum, and Phaeotheca triangularis, indicating that 17beta-HSD activity is widely distributed among yeast. In extremophilic black yeast, NaCl modulated enzyme activity. Enzymes resembling 17beta-HSD from the filamentous fungus Cochliobolus lunatus were detected in Trimmatostroma salinum and Phaeotheca triangularis. Sequences with identity to the Saccharomyces cerevisiae YBR159w gene were not observed in other yeast speciespossessing a similar enzyme activity. The results suggest the existenceof at least three different types of 17beta-HSD in yeast.
    Vir: Steroids. - ISSN 0039-128X (Letn. 66, št. 1, 2001, str. 49-54)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - angleški
    COBISS.SI-ID - 12915161
vir: Steroids. - ISSN 0039-128X (Letn. 66, št. 1, 2001, str. 49-54)
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