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  • Telomere in telomeraza pri človeku - zgradba, funkcija in vloga v procesu kancerogeneze = Human telemore and telomerase: structure, function and role in cancerogenesis
    Luzar, Boštjan ...
    With each somatic cell division; the chromosomal ends, or telomeres, progressively shorten. Critically shortened telomeres are recognised by DNA repair systems as DNA damage, the cells are withdrawn ... from the cell cycle, senesce and eventually die. Mutations in the genes responsible for cell division cycle control, or repression of their protein products, enable cells to continue their proliferation. In the period of the so-called extended life span the cells acquire additional genetic mutations, telomeres progressively shorten, and genomic instability increases. Due to the extremely shortened telomeres accompanied by accumulation of genetic abnormalities and increased genomic instability, most cells enter the period of crisis and die. Those cells that can preveni telomere shortening escape crisis and continue to proliferate. Due to the stabilised telomeres they have the ability to proliferate indefinitely. The only known mechanism so far by which human cellscan regulate the length of telomeres is by the action of the enzyme telomerase. Detection of telomexase activity in the overwhelming majority of advanced and metastatic human cancer but not in most somatic cells implies that telomerase dependent mmorEalization could contribute to the development of malignancy. Thus, repression of telomerase activity may be a novel adjuvanttherapy for the treatment of human cancer and detection of telomerase activity may be important for cancer diagnostic. In the present review we havedescribed the most recent advances in the field of telomeres and telomere related proteins, the so-called telomeric complex, its structure and function.Furthermore, we have also outlined the structure, function and mechanisms, by which telomerase regulates the length of human telomeres. Finally, the current views on the role of telomerase in human cancerogenesis are presented.
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 39, št. 3, september 2000, str. 271-279)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 13017305

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    Digitalna knjižnica Slovenije - dLib.si

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