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Multiscale femoral neck imaging and multimodal trabeculae quality characterization in an osteoporotic bone sample [Elektronski vir]Soldati, Enrico ...Although multiple structural, mechanical, and molecular factors are definitely involved in osteoporosis, the assessment of subregional bone mineral density remains the most commonly used diagnostic ... index. In this study, we characterized bone quality in the femoral neck of one osteoporotic patients as compared to an age-matched control subject, and so used a multiscale and multimodal approach including X-ray computed microtomography at different spatial resolutions (pixel size: 51.0, 4.95 and 0.9 µm), microindentation and Fourier transform infrared spectroscopy. Our results showed abnormalities in the osteocytes lacunae volume (358.08 ± 165.00 for the osteoporotic sample vs. 287.10 ± 160.00 for the control), whereas a statistical difference was found neither for shape nor for density. The osteoporotic femoral head and great trochanter reported reduced elastic modulus (Es) and hardness (H) compared to the control reference (−48% (p < 0.0001) and −34% (p < 0.0001), respectively for Es and H in the femoral head and −29% (p < 0.01) and −22% (p < 0.05), respectively for Es and H in the great trochanter), whereas the corresponding values in the femoral neck were in the same range. The spectral analysis could distinguish neither subregional differences in the osteoporotic sample nor between the osteoporotic and healthy samples. Although, infrared spectroscopic measurements were comparable among subregions, and so regardless of the bone osteoporotic status, the trabecular mechanical properties were comparable only in the femoral neck. These results illustrate that bone remodeling in osteoporosis is a non-uniform process with different rates in different bone anatomical regions, hence showing the interest of a clear analysis of the bone microarchitecture in the case of patients’ osteoporotic evaluationVir: Materials [Elektronski vir]. - ISSN 1996-1944 (Vol. 15, iss. 12, 2022, str. 1-24)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2022Jezik - angleškiCOBISS.SI-ID - 136456195
Avtor
Soldati, Enrico |
Roseren, Flavy |
Guenoun, Daphne |
Mancini, Lucia |
Catelli, Emilio |
Prati, Silvia |
Sciutto, Giorgia |
Vicente, Jerome |
Iotti, Stefano |
Bendahan, David |
Malucelli, Emil |
Pithioux, Martine
Teme
sinhrotronska rentgenska mikrotomografija |
kosti |
trabekularna struktura |
osteoni |
osteoporoza |
slikanje s faznim kontrastom |
odprti dostop |
synchrotron X-ray microtomography |
bone |
trabecular struicture |
osteons |
osteoporosis |
phase-contrast imaging |
open access
Avtor | Soldati, Enrico ... |
Naslov | Multiscale femoral neck imaging and multimodal trabeculae quality characterization in an osteoporotic bone sample [Elektronski vir] |
Datum objave | 2022-11-14 |
COBISS.SI-ID | 136456195 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE | Amidex | 11-IDEX-0001 |
French National Research Agency (ANR) |
International, inter-sectoral and inter-disciplinary Doctoral Training Programme to Aix-Marseille University | DOC2AMU | 713750 |
European Commission |
Datoteke, ki spadajo k objavi
Povezava |
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https://www.mdpi.com/1996-1944/15/22/8048 |
https://dirros.openscience.si/IzpisGradiva.php?id=16089 |
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Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Soldati, Enrico | |
Roseren, Flavy | |
Guenoun, Daphne | |
Mancini, Lucia | 56577 |
Catelli, Emilio | |
Prati, Silvia | |
Sciutto, Giorgia | |
Vicente, Jerome | |
Iotti, Stefano | |
Bendahan, David | |
Malucelli, Emil | |
Pithioux, Martine |
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