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13.
Proliferative and apoptotic activity in hepatocellular carcinoma and surrounding non-neoplastic liver tissue
Pižem, Jože ...
The aim of the study was to determine the proliferative and apoptotic activityof neoplastic and nonneoplastic hepatocytes, to ascertain whether there was a correlation between the histopathological ...characteristics of hepatocellular carcinoma (HCC) and its proliferative or apoptotic activity. Methods. One tumour sample and one sample of nonneoplastic liver from 16 patients with HCC were analysed. The proliferative activity was established byimmunohistochemical staining against PCNA (proliferating cell nuclear antigen) and Ki-67. Apoptotic activity was determined by morphological and TUNEL methods. Bcl-2 immunoreactivity was analysed. Results. A positive correlation between PCNA and Ki-67 proliferative indexes was found in HCC (p<0.01). The PCNA index was 0.21 % +- 0.80% (Mean +- SD) in nonneoplastic liver and 7.41% +- 8.22% in HCC, while the Ki67 index was 0.19% +- 0.26% in non-neoplastic liver and 9.67% +- 7.70% in HCC. The differences between HCC and non-neoplastic liver were significant (p<0.05). The PCNA index differed significantly between different HCC grades (p<0.05). In HCC and non-neoplasticliver samples, apoptotic indexes (AI) assessed morphologically were higher than AI determined by the TUNEL method. Differences in AI (irrespective of the method used) between different HCC grades were not significant. Bcl-2 staining was positive in one non-neoplastic liver sample (6.3%) and in 4 HCC samples (25%). Conclusions. PCNA and Ki-67 were useful forproliferative activity assessment of hepatocytes. There were no differencesin apoptotic activity between HCC and nonneoplastic tissue, so it seems that uncontrolled tumour cell division plays an important role in HCC growth. In the regulation of the apoptotic process in HCC, Bcl-2 could be important.
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