-
Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surfaceJurišić Dukovski, Bisera ...Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly ... soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and other formulation components and consequent replenishment and stabilization of the compromised tear film. Ophthalmic NEs have been on the market for over 20 years, but considering their complexity, as well as the complex nature of the ocular surface, they are still a poorly understood advanced dosage form. The objective of this study was to develop a biorelevant in vitro method that would be able to predict the behavior of ophthalmic NEs after application. With that goal, NE formulations differing in critical material attributes and critical formulation variables were employed and subjected to simulated tear turnover and blinking. By gradually increasing the complexity of the in vitro method, we were able to detect key parameters influencing NE stability. The undertaken study presents a step forward in the development of in vitro tools that are fundamental to the reliable, cost and time-effective development of innovative and generic topical ophthalmic NEs.Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 633, art. 122622, 2023, 11 str.)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 139859459
Avtor
Jurišić Dukovski, Bisera |
Josip, Ljubica |
Kocbek, Petra, farmacevtka |
Safundžić Kučuk, Maša |
Krtalić, Iva, farmacevtka |
Hafner, Anita |
Pepić, Ivan |
Lovrić, Jasmina
Teme
Nanomateriali |
eye drops |
nanoemulsion |
chitosan |
dilution |
high shear |
dynamic light scattering |
kapljice za oko |
nanoemulzije |
dinamično sipanje svetlobe |
visoko striženje
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Avtor | Jurišić Dukovski, Bisera ... |
Naslov | Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface |
Datum objave | |
COBISS.SI-ID | 139859459 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
FarmInova | IP-2019-04-2174 | ||
BioProspecting of the Adriatic Sea | BioProCro | KK.01.1.1.02 |
European Commission Croatian Science Foundation (CSF) |
Young researchers’ career development project – training of new doctoral students | DOK-2020-01-4932 |
Datoteke, ki spadajo k objavi
Povezava |
---|
![]() |
![]() |
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Jurišić Dukovski, Bisera | ![]() |
Josip, Ljubica | ![]() |
Kocbek, Petra, farmacevtka | 24402 |
Safundžić Kučuk, Maša | ![]() |
Krtalić, Iva, farmacevtka | ![]() |
Hafner, Anita | ![]() |
Pepić, Ivan | ![]() |
Lovrić, Jasmina | ![]() |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.