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  • Binding of Tat to TAR and recruitment of positive transcription elongation factor b occur independently in bovine immunodeficiency virus
    Barborič, Matjaž, 1975- ...
    Transcriptional transactivators (Tat) from many lentiviruses interact with their cognate transactivation response RNA structures (TAR) to increase rates of elongation rather than initiation of ... transcription. For several of them, the complex of Tat and a species-specific cyclin T1 must be formed before the binding to TAR can occur with high affinity and specificity. In sharp contrast, Tat from the bovine immunodeficiency virus (BIV) binds to its TAR without the help of the cyclin T1. This binding depends on the upper stem and 5' bulge, but not the central loop in TAR. Moreover, cyclins T1 from differentspecies can mediate effects of this Tat in cells. Unlike the situation with other lentiviruses, Tat transactivation can be rescued simply by linking a heterologous promoter to TA in permissive cells. Thus, lentiviruses have evolved different strategies to recruit Tat and the positivetranscription elongation factor b to their promoters, and interactionsbetween Tat and TAR are independent from those between Tat and thecyclin T1 in BIV.
    Vir: Journal of virology. - ISSN 0022-538X (Letn. 74, št. 13, 2000, str. 6039-6044)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 14007257

vir: Journal of virology. - ISSN 0022-538X (Letn. 74, št. 13, 2000, str. 6039-6044)
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