-
Neutrophil to lymphocyte ratio in oropharyngeal squamous cell carcinoma [Elektronski vir] : a systematic review and meta-analysisRodrigo, Juan Pablo ...Neutrophil-to-lymphocyte ratio (NLR) has been associated with survival in various cancers, including head and neck cancer. However, there is limited information on its role in oropharyngeal squamous ... cell carcinomas (OPSCC) according to HPV status. This prompted the present meta-analysis. Studies were selected when the prognostic value of NLR prior to treatment was evaluated in OPSCC patients, the cutoff value of NLR was available, and the prognostic value of NLR was evaluated by time-to-event survival analysis. A total of 14 out of 492 articles, including 7647 patients, were analyzed. The results showed a worse prognosis for the patients with a high NLR: The combined hazard ratios (HR) for overall survival (OS) in patients with an elevated NLR was 1.56 (95% confidence interval (CI) 1.21–2.02; p = 0.0006), for disease-free survival was 1.52 (95% CI 1.34–1.73; p < 0.00001), and for recurrence-free survival was 1.86 (95% CI 1.50–2.30; p < 0.00001). This worse prognosis of high NLR was exclusive of HPV-positive patients: HR for OS in the HPV-positive subgroup was 4.05 (95% CI 1.90–8.62 (p = 0.0003), and in the HPV-negative subgroup 0.92 (95% CI 0.47–1.80; p = 0.82). The prognosis of NLR was not influenced by treatment: The HR for OS for patients treated with radiotherapy/chemoradiotherapy (RT/CRT) was 1.48 (95% CI 1.09–2.01; p = 0.01), and for patients treated with surgery (±RT/CRT) was 1.72 (95% CI 1.08–2.72; p = 0.02). In conclusion, an elevated NLR relates to worse outcomes in patients with HPV-positive OPSCC.Vir: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 15, no. 3, [article no.] 802, 2023, str. 1-13)Vrsta gradiva - e-članekLeto - 2023Jezik - angleškiCOBISS.SI-ID - 148627715
Avtor
Rodrigo, Juan Pablo |
Sánchez-Canteli, Mario |
Triantafyllou, Asterios |
De Bree, Remco |
Mäkitie, Antti A. |
Franchi, Alessandro |
Hellquist, Henrik |
Saba, Nabil F. |
Stenman, Göran |
Zidar, Nina, 1960-
Teme
orofaringealni ploščatocelični karcinom |
meta-analiza |
razmerje med nevtrofilci in limfociti |
oropharyngeal squamous cell carcinoma |
meta-analysis |
neutrophil-to-lymphocyte ratio
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Rodrigo, Juan Pablo | ![]() |
Sánchez-Canteli, Mario | ![]() |
Triantafyllou, Asterios | ![]() |
De Bree, Remco | ![]() |
Mäkitie, Antti A. | ![]() |
Franchi, Alessandro | ![]() |
Hellquist, Henrik | ![]() |
Saba, Nabil F. | ![]() |
Stenman, Göran | ![]() |
Zidar, Nina, 1960- | 12955 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.