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Interleukin-18 is a potential biomarker linking dietary fatty acid quality and insulin resistance [Elektronski vir] : results from a cross-sectional study in Northern ItalySergi, Domenico ...Dietary lipids are pivotal in modulating metabolic inflammation. Among the inflammatory mediators characterizing metabolic inflammation, interleukin 18 (IL-18) has been consistently associated with ... obesity and insulin resistance. This study aims to evaluate whether the quality of lipid intake impacts upon IL-18 plasma levels and the implications on insulin resistance computed by the homeostatic model assessment for insulin resistance (HOMA-IR). Using a cross-sectional design, this study confirmed that IL-18 correlated positively with insulin resistance and individuals with a HOMA-IR ≥ 2.5 displayed higher circulating IL-18 levels compared with their insulin-sensitive counterparts. In terms of the effect of the quality of dietary lipids on IL-18 circulating levels, the ratio between monounsaturated, omega-3, polyunsaturated and saturated fatty acids as well as the intake of eicosapentaenoic and docosahexaenoic acids correlated negatively with IL-18. Despite this, IL-18 circulating levels, but not dietary fatty acid quality, predicted insulin resistance. Nevertheless, the ratio between omega 3 and saturated fatty acids was a predictor of IL-18 plasma levels. Thus, the downregulation of IL-18 may underpin, at least partially, the beneficial metabolic effects of substituting omega 3 for saturated fatty acids with this cytokine potentially representing a biomarker linking dietary lipids and metabolic outcomes.Vir: Nutrients [Elektronski vir]. - ISSN 2072-6643 (Vol. 15, iss. 7, [article no.] 1782, 2023, 14 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 149163779
Avtor
Sergi, Domenico |
Sanz, Juana Maria |
Lazzer, Stefano |
Brombo, Gloria |
Zuliani, Giovanni |
Biolo, Gianni |
Šimunič, Boštjan |
Pišot, Rado |
Dalla Nora, Edoardo |
Passaro, Angelina
Teme
IL-18 |
metabolno vnetje |
inzulinska rezistenca |
nasičene maščobne kisline |
mononenasičene maščobne kisline |
omega-3 maščobne kisline |
polinenenasičene maščobne kisline |
metabolic inflammation |
insulin resistance |
saturated fatty acids |
monounsaturated fatty acids |
omega-3 fatty acids |
polyunsaturated fatty acids
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Sergi, Domenico | |
Sanz, Juana Maria | |
Lazzer, Stefano | |
Brombo, Gloria | |
Zuliani, Giovanni | |
Biolo, Gianni | 51191 |
Šimunič, Boštjan | 21102 |
Pišot, Rado | 11612 |
Dalla Nora, Edoardo | |
Passaro, Angelina |
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