VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • A study of the role of histamine in gastric secretion in the isolated guinea pig gastric preparation
    Stanovnik, Lovro ; Logonder-Mlinšek, Metka ; Erjavec, Franc, 1925-2005
    Mast cell histamine could be involved in the regulation of gastric acid secretion. In order to compare the results on mast cell histamine obtained in experiments carried out on the isolated mouse ... stomach to guinea pig stomach, the method for isolated mouse stomach was adapted to isolated stomach wall of the guinea Pig. The modified preparation gave repeatable secretory responses to histamine and carbachol, similar to those in the isolated mouse stomach. Compound 48/80 (100 microg/ml) did not evoke secretion, whereas a calcium ionophore, chlortetracycline (CTC), reduced basal secretion, as did low concentrations ( less th. 100 nmol/1) of histamine; chloropyramine (100 micromol/1) counteracted the inhibitory effect of histamine. Histological examination of the guinea pig gastric mucosa showed more connective tissue mast cells (CTMC) than mucosal mast cells (MMC). CTMC were degranulated in response to chlortetracycline but not to compound 48/80.
    Vir: Agents and actions. - ISSN 0065-4299 (1992, Str. C372-5)
    Vrsta gradiva - članek, sestavni del
    Leto - 1992
    Jezik - angleški
    COBISS.SI-ID - 1494489

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