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  • The shape anisotropy of magnetic nanoparticles : an approach to cell-type selective and enhanced internalization
    Potrč, Tanja, farmacevtka ...
    The effects of the shape anisotropy of nanoparticles on cellular uptake is still poorly understood due to challenges in the synthesis of anisotropic magnetic nanoparticles of the same composition. ... Here, we design and synthesize spherical magnetic nanoparticles and their anisotropic assemblies, namely magnetic nanochains (length ∼800 nm). Then, nanoparticle shape anisotropy is investigated on urothelial cells in vitro. Although both shapes of nanomaterials reveal biocompatibility, we havefound significant differences in the extent of their intracellular accumulation. Contrary to spherical particles, anisotropic nanochains preferentially accumulate in cancer cells as confirmed by inductively coupled plasma (ICP) analysis, indicating that control of the nanoparticle shape geometry governs cell-type-selective intracellular uptake and accumulation.
    Vir: Nanoscale. - ISSN 2040-3364 (Vol. 15, iss.19, 2023, str. 8611-8618)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 150543875

    Povezava(-e):

    https://pubs.rsc.org/en/content/articlelanding/2023/nr/d2nr06965b
    Repozitorij Univerze v Ljubljani – RUL
    DOI

vir: Nanoscale. - ISSN 2040-3364 (Vol. 15, iss.19, 2023, str. 8611-8618)
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