-
Modeling of molecular and cellular mechanisms involved in [Ca sup 2+] signal encoding in airway myocytesMarhl, Marko ; Noble, Denis ; Roux, EtienneIn airway myocytes signal transduction via cytosolic calcium plays an important role. In relation with experimental results we review models of basic molecular and cellular mechanisms involved in the ... signal transduction from the myocyte stimulation to the activation of the contractile apparatus. We concentrate on mechanisms for encoding of input signals into Ca2+ signals and the mechanisms for their decoding. The mechanisms are arranged into a general scheme of cellular signaling, the so-called bow-tie architecture of signaling, in which calcium plays the role of a common media for cellular signals and links the encoding and decoding part. The encoding of calcium signals in airway myocytes is better known and is presented in more detail. Inparticular, we focus on three recent models taking into account the intracellular calcium handling and ion fluxes through the plasma membrane. Themodel of membrane conductances was originally proposed for predicting membrane depolarization and voltage-dependent Ca2+ influx triggered by initialcytosolic Ca2+ increase as observed on cholinergic stimulation. Cellular models of intracellular Ca2+ handling were developed to investigate the role of a mixed population of InsP3 receptor isoforms and the cellular environment in the occurrence of Ca2+ oscillations, and the respective role ofthe sarcoplasmic reticulum, mitochondria, and cytosolic Ca2+-binding proteins in cytosolic Ca2+ clearance. Modeling the mechanisms responsible for the decoding of calcium signals is developed in a lesser extent; however, the most recent theoretical studies are briefly presented in relation with the known experimental results.Vir: Cell biochemistry and biophysics. - ISSN 1085-9195 (Vol. 46, no. 3, 2006, str. 285-302)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2006Jezik - angleškiCOBISS.SI-ID - 15169288
Avtor
Marhl, Marko |
Noble, Denis |
Roux, Etienne
Teme
Biofizika |
biofizika |
matematično modeliranje |
modeliranje |
kalcijeve oscilacije |
gladke mišice |
krčenje mišic |
vkodiranje |
dekodiranje |
matematični modeli |
ne zaključna dela |
biophysics |
mathematical modelling |
modelling |
calcium oscillations |
contractions |
airway smooth muscle cells |
muscle cells |
smooth muscles |
encoding |
decoding |
bow-tie structures
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Marhl, Marko | 13159 |
Noble, Denis | |
Roux, Etienne |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.