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  • Cinnamic acid esters as potent inhibitors of fungal 17ß-hydroxysteroid dehydrogenase-a model enzyme of the short-chain dehydrogenase/reductase superfamily
    Gobec, Stanislav, 1970- ...
    We present the synthesis of a new family of nonsteroidal inhibitors of 17ß-hydroxysteroid dehydrogenase, designed from flavones and chalcones. Their inhibitory potential was screened on ... 17ß-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17ß-HSDcl), a model enzyme of the short-chain dehydrogenasežreductase superfamily. In a series of cinnamates and related coumarin-3-carboxylates, a number of compounds proved to be potent inhibitors of both the oxidative and reductive reactions catalyzed by 17ß-HSDcl, with IC50values in the low micromolar range.
    Vir: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 14, no. 15, 2004, str. 3933-3936)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 1532273