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Influence of polymer concentration on drying of SPION dispersions by electrospinning [Elektronski vir]Dragar, Črt ...To improve the physical stability of nanoparticle dispersions, several methods for their transformation into stable and easily dispersible dry products have been investigated thus far. Recently, ... electrospinning was shown to be a novel nanoparticle dispersion drying method, which addresses the crucial challenges of the current drying methods. It is a relatively simple method, but it is affected by various ambient, process, and dispersion parameters, which impact the properties of the electrospun product. The aim of this study was, thus, to investigate the influence of the most important dispersion parameter, namely the total polymer concentration, on the drying method efficiency and the properties of the electrospun product. The formulation was based on a mixture of hydrophilic polymers poloxamer 188 and polyethylene oxide in the weight ratio of 1:1, which is acceptable for potential parenteral application. We showed that the total polymer concentration of prior-drying samples is closely related to their viscosity and conductivity, also affecting the morphology of the electrospun product. However, the change in morphology of the electrospun product does not affect the efficiency of SPION reconstitution from the electrospun product. Regardless of the morphology, the electrospun product is not in powder form and is therefore safer to handle compared to powder nanoformulations. The optimal total polymer concentration in the prior-drying SPION dispersion, which enables the formation of an easily dispersible electrospun product with high SPION-loading (65% (w/w)) and fibrillar morphology, was shown to be 4.2% (w/v).Vir: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 15, iss. 6, art. 1619, 2023, 22 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 153958147
Avtor
Dragar, Črt |
Rekar, Žan, farmacevt |
Potrč, Tanja, farmacevtka |
Nemec, Sebastjan, farmacevt |
Kralj, Slavko, 1983- |
Kocbek, Petra, farmacevtka
Teme
Sušenje |
Nanovlakna |
elektropredenje |
poloksamer 188 |
polietilen oksid |
superparamagnetni nanodelci železovega oksida |
drying |
electrospinning |
nanofibers |
poloxamer 188 |
polyethylene oxide |
superparamagnetic iron oxide nanoparticles
Avtor | Dragar, Črt ... |
Naslov | Influence of polymer concentration on drying of SPION dispersions by electrospinning [Elektronski vir] |
Datum objave | 2023-05-30 |
COBISS.SI-ID | 153958147 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
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Datoteke, ki spadajo k objavi
Povezava |
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https://www.mdpi.com/1999-4923/15/6/1619 |
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Dragar, Črt | 53585 |
Rekar, Žan, farmacevt | 57084 |
Potrč, Tanja, farmacevtka | 37548 |
Nemec, Sebastjan, farmacevt | 52055 |
Kralj, Slavko, 1983- | 29529 |
Kocbek, Petra, farmacevtka | 24402 |
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