VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Evaluating cancer screening programs using survivalanalysis
    Vratanar, Bor ; Pohar Perme, Maja
    The main purpose of cancer screening programs is to provide early treatmentto patients that are diagnosed with cancer on a screening test, thus increasingtheir chances of survival. To test this ... hypothesis directly, one should comparethe survival of screen-detected cases to the survival of their counterparts notincluded to the program. In this study, we develop a general notation and useit to formally define the comparison of interest. We explain why the naive com-parison between screen-detected and interval cases is biased and show that thetotal bias that arises in this case can be decomposed as a sum of lead time bias,length time bias, and bias due to overdetection. With respect to the estimation,we show what can be estimated using existing methods. To fill in the missinggap, we develop a new nonparametric estimator that allows us to estimate thesurvival of the control group, that is, the survival of cancer cases that would bescreen-detected among those not included to the program. By joining the pro-posed estimator with existing methods, we show that the contrast of interest canbe estimated without neglecting any of the biases. Our approach is illustratedusing simulations and empirical data.
    Vir: Biometrical journal. - ISSN 0323-3847 (Vol. , iss. , 2023, str.)
    Vrsta gradiva - članek, sestavni del
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 154649603

    Povezava(-e):

    Repozitorij Univerze v Ljubljani – RUL
    DOI

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