VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Novel non-covalent azaphenylalanine thrombin inhibitors with an aminomethyl or amino group at the P1 position
    Obreza, Aleš ; Stegnar, Mojca ; Urleb, Uroš
    Design, synthesis and biological evaluation of a series of novel non-covalent azaphenylalanine thrombin inhibitors are presented. Replacement of the basic benzamidine moiety in azaphenylalanine ... derivatives by benzylamine (P1 part of a molecule) and the introduction of a N-cyclopentyl-N-methylamine moiety in the P2 part of a molecule resulted in the thrombin inhibitor LK-733 with greatly increased selectivity against trypsin and an in vitro Ki of 31 nM.
    Vir: Pharmazie. - ISSN 0031-7144 (Vol. 59, no. 9, 2004, str. 659-666)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 1564017

vir: Pharmazie. - ISSN 0031-7144 (Vol. 59, no. 9, 2004, str. 659-666)
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