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  • Genetic complexity of an obesity QTL (Fob3) revealed by detailed genetic mapping
    Stylianou, Ioannis Mastroufis ...
    Obesity is proving to be a serious helath concern in the developed world as well as an unwanted component of growth in livestock production. While recent advances in genetic have identified a number ... of monogenic causes of obesity, these are responsible for only a small proportion of human cases of obesity. By divergent selection for high and low fat content over 60 generations, we have created Fat (F) and Lean (L) lines of mice that represent a model of polygenic obesity similar to the situation in human populations. From previous crosses of these lines, four body fat quantitative trait loci (QTL) were identified. We have created congenic lines(F[up]chr15L), by recurrent marker-assisted baccrossing, to introgress the QTL region with the highest LODscore, Fob3 on Chr 15, from the L-Ine into the F-line background. We have further mapped this QTL by progeny testing of recombinants, produced from crosses between the F-line and congenic F[up]chr15L mice, showing that the Fob3 QTL region is a composite of at least two smaller effect QTL-the proximalQTL Fob3a is a late-onset obesityQTL, wherreas the distal Fob3b is an early-onset obesity QTL.
    Vir: Mammalian genome. - ISSN 0938-8990 (Letn. 15, 2004, str. 472-481)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 1579912

vir: Mammalian genome. - ISSN 0938-8990 (Letn. 15, 2004, str. 472-481)
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