VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Selective regulation of protein activity by complex ▫$Ca^{2+}$▫ oscillations
    Knoke, Beate ; Marhl, Marko ; Schuster, Stefan
    Calcium oscillations play an important role in intracellular signal transduction. As a second messenger, ▫$Ca^{2+}$▫ represents a link between several input signals and several target processes in ... the cell. Whereas the frequency of simple ▫$Ca^{2+}$▫ oscillations enables a selective activation of a specific protein and herewith a particular process, the question arises of how at the same time two or more classes of proteins can be specifically regulated. The question is general and concerns the problem of how one second messenger can transmit more than one signal simultaneously (bow-tie structure of signalling). To investigate whether a complex ▫$Ca^{2+}$▫ signal like bursting, a succession of low-peak and high-peak oscillatory phases, could selectively activate different proteins, several bursting patterns with simplified square pulses were applied in a theoretical model. The results indicate that bursting ▫$Ca^{2+}$▫ oscillations allow a differential regulation of two different calcium-binding proteins, and hence, perform the desired function.
    Vir: Mathematical modeling of biological systems. Vol. 1, Cellular biophysics, regulatory networks, development, biomedicine, and data analysis (Str. 11-22)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 15940360

    Povezava(-e):

    http://dx.doi.org/10.1007/978-0-8176-4558-8_2
    Digitalna knjižnica Univerze v Mariboru – DKUM

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