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  • Patients with chronic spontaneous urticaria who have wheals, angioedema, or both, differ demographically, clinically, and in response to treatment [Elektronski vir] : results from CURE
    Buttgereit, Thomas ...
    Background. Patients with chronic spontaneous urticaria (CSU) have spontaneous wheals, angioedema, or both for >6 weeks. Clinical differences between patients with standalone wheals (W), standalone ... angioedema (AE), and wheals and angioedema (W+AE) remain incompletely understood. Objective. To compare W, AE, and W+AE CSU patients regarding demographics, disease characteristics, comorbidities, disease burden, and treatment response. Methods. Baseline data from 3,698 CSU patients in the ongoing, prospective, international, multicenter, observational Chronic Urticaria Registry were analysed (CURE; data cut: September 2022). Results. Across all CSU patients, 59%, 36%, and 5% had W+AE, W, and AE, respectively. W+AE patients, compared with W and AE patients, showed the lowest male/female ratio (0.33), higher rates of concomitant psychiatric disease (17% vs 11% vs 6%), autoimmune disease (13% vs 7% vs 9%), and NSAID hypersensitivity (9% vs 5% vs 2%) and the highest disease impact. W patients, compared with W+AE and AE patients, showed the lowest rates of concomitant hypertension (15% vs 21% vs 40%) and obesity (11% vs 16% vs 17%), the highest rate of concomitant inducible urticaria (24% vs 22% vs 6%) and shorter wheal duration. AE patients, as compared to W+AE and W patients, were older at disease onset, showed longer angioedema duration and the best response to increased doses of H1-antihistamines (58% vs 24% vs 31%) and omalizumab (92% vs 67% vs 60%). Conclusion. Our findings provide a better understanding of CSU phenotypes and may guide patient care and research efforts that aim to link them to pathogenic drivers.
    Vir: The journal of allergy and clinical immunology. In practice [Elektronski vir]. - ISSN 2213-2201 (Vol. 11, iss. 11, Nov. 2023, str. 3515-3525.e4)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 162639875

    Povezava(-e):

    https://www.sciencedirect.com/science/article/abs/pii/S2213219823009248

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