-
A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFbZhang, Fan, medicina ...The positive transcription elongation factor b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9). For activating the expression ofeukaryotic genes, the histidine-rich sequence ... in CycT1 binds the heptapeptide repeats in the C-terminal domain (CTD) of RNA polymerase II (RNAPII), whereupon Cdk9 phosphorylates the CTD. We found that alanine-substituted heptapeptide repeats that cannot be phosphorylated also bind CycT1. When placed near transcription units, these CTD analogs block effects of P-TEFb. Remarkably, the transcriptional repressor PIE-1 from Caenorhabditis elegans behaves analogously. It binds CycT1 via an alanine-containing heptapeptide repeat and inhibits transcriptional elongation. Thus, our findings reveal a new mechanism by which repressors inhibit eukaryotic transcription.Vir: Genes & development. - ISSN 0890-9369 (Letn. 17, št. 6, 2003, str. 748-758)Vrsta gradiva - članek, sestavni delLeto - 2003Jezik - angleškiCOBISS.SI-ID - 16469465
Avtor
Zhang, Fan, medicina |
Barborič, Matjaž, 1975- |
Blackwell, T. Keith |
Peterlin, Matija Boris
Teme
Nuclear Proteins |
Physiology |
Genetics |
Protein-Serine-Threonine Kinases |
Genetics |
Physiology |
Rna Polymerase Ii |
Chemistry |
Metabolism |
Alanine |
Chemistry |
Binding Sites |
Binding, Competitive |
Blotting, Western |
COS Cells |
Caenorhabditis Elegans |
Cyclin-Dependent Kinases |
Metabolism |
Glutamic Acid |
Chemistry |
Hela Cells |
Histidine |
Chemistry |
Models, Genetic |
Mutation |
Peptides |
Chemistry |
Phosphorylation |
Plasmids |
Metabolism |
Protein Binding |
Ribonucleases |
Metabolism |
Serine |
Metabolism |
Trans-Activation (Genetics) |
Transcription, Genetic |
Transfection |
Beljakovina-serin-treoninska kinaza |
Jedrne beljakovine |
RNA polimeraza II |
Alanin |
Beljakovine, vezava |
Blot, Western |
COS celice |
Caenorhabditis elegans |
Ciklin-odvisne kinaze |
Fosforilacija |
Glutaminska kislina |
Hela celice |
Histidin |
Mesta vezave |
Modeli genetski |
Mutacija |
Peptidi |
Plazmidi |
Ribonukleaze |
Serin |
Trans-aktivacija (genetika) |
Transfekcija |
Transkripcija genetična |
Vezava kompetitivna
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Zhang, Fan, medicina | ![]() |
Barborič, Matjaž, 1975- | 20346 |
Blackwell, T. Keith | ![]() |
Peterlin, Matija Boris | 34721 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.