VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Conjugates of monocyclic β-lactams and siderophore mimetics : a patent evaluation (WO2023023393)
    Krajnc, Alen, Farmacija, 1994 ; Gobec, Stanislav, 1970-
    Introduction: β-Lactams, which include monobactams, remain the most important class of antibiotics worldwide. Aztreonam, the only monobactam in clinical use, has remarkable activity against many ... Gram-negative bacteria, but limited activity against some of the most problematic multidrug-resistant (MDR) pathogens, such as MDR Pseudomonas aeruginosa and Acinetobacter baumannii co-expressing extended-spectrum- and metallo-β-lactamases, which can inactivate aztreonam by hydrolysis. Areas covered: Structurally novel siderophore-conjugated aztreonam derivatives with improved antibacterial properties against several high-priority pathogens are claimed. This invention reports that sidechain extension of aztreonam is tolerated; the coupling of its aminothiazoloxime carboxylic acid part with a siderophore mimetic significantly improved the antibacterial activity against several problematic strains, including MDR A. baumannii isolates with carbapenemase/cephalosporinase activity. Expert Opinion: Finding new strategies to tackle bacterial resistance to β-lactam antibiotics is critical. Considering that β lactams are validated and safe drugs, this research may stimulate the field to develop new ideas in the arena of antimicrobial drug discovery, particularly with respect to siderophore mimetics.
    Vir: Expert opinion on therapeutic patents. - ISSN 1354-3776 (Vol. 33, iss. 7-8, 2023, str. 471-476)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 171047171

    Povezava(-e):

    https://www.tandfonline.com/doi/full/10.1080/13543776.2023.2262135
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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