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Satisfaction with pharmacotherapy for approved and off-Label indications-A delphi studyKos, Mitja, 1973- ; Wertheimer, Albert I. ; Mrhar, AlešBACKGROUND: Prescribing for non-approved uses is widespread in the treatment of AIDS, cancer, and pediatric illnesses, but it is by no means limited to these areas. Few studies have been performed ... evaluating reasons for off-label prescribing. OBJECTIVEČ To explore the satisfaction with drug therapy as one of the potential reasons for off-label uses by testing a hypothesis that the satisfaction with drug therapy for off-label indications is lower than for approved indications. METHODS: The study compared the satisfaction with drug therapy for known off-label indications with a control group of approved indications. Twenty-four of the first 50 single-ingredient drugs, according totheir share in the drug cost budget of the Slovenian Compulsory Health Insurance, had 86 different off-label indications eligible for inclusion. A control group of 86 approved indications was randomly selected from the list of all possible approved indications for the same 24 drugs. A 2-round Delphi technique, involving an expert panel of physicians who are members of the drugregulatory agency, was used to evaluate the satisfaction with drug therapyfor selected indications. RESULTS: After the second round of the Delphistudy, the median scores of satisfaction with drug therapy for approved and off-label indications were 7.00 and 6.50, respectively (p = 0.001). CONCLUSIONS: The study shows that the satisfaction with available drug therapyfor off-label indications is lower than for approved indications. The statistical association, biologic plausibility, and coherence with existing information, as well as the temporality of the association, provide supportingevidence that low satisfaction with drug therapy is one of the incentives for off-label use.Vir: The Annals of pharmacotherapy. - ISSN 1060-0280 (Vol. 39, no. 4, 2005, str. 649-654)Vrsta gradiva - članek, sestavni delLeto - 2005Jezik - angleškiCOBISS.SI-ID - 1711729
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kos, Mitja, 1973- | 20374 |
Wertheimer, Albert I. | |
Mrhar, Aleš | 06086 |
Vir: Osebne bibliografije
in: SICRIS
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