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  • Paricalcitol as an antiproteinuric agent can result in the deterioration of renal and heart function in a patient with Fabry disease [Elektronski vir]
    Keber, Tajda, 1989- ...
    BACKGROUND: Fabry disease is a rare and progressive X-linked inherited disorder of glycosphingolipid metabolism that is due to deficient or absent lysosomal a-galactosidase A activity. Among its ... other associated signs and symptoms, patients present with renal failure and proteinuria, which are markers of disease progression. Renin-angiotensin-aldosterone system (RAAS) blockers can slow the progression of chronic renal failure and proteinuria. In fact, some studies have shown the beneficial effects of paricalcitol on proteinuria. CASE REPORT: We present a case of a female patient with the classic variant of Fabry disease. She was treated with a high dose of paricalcitol as an antiproteinuric agent due to unsatisfactory double-RAAS blockage, which resulted in transient worsening of cardiac and renal function. CONCLUSIONS: Despite the positive effects of paricalcitol as an antiproteinuric agent, as previously shown by some authors, our case highlights the possible serious adverse effects associated with the use of high doses of this drug.
    Vir: The American journal of case reports [Elektronski vir]. - ISSN 1941-5923 (Vol. 18, 2017, str. 644-648)
    Vrsta gradiva - e-članek
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 17195316

    Povezava(-e):

    https://www.amjcaserep.com/abstract/index/idArt/903886
    DOI

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