VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Naše izkušnje zdravljenja bolnikov z dlakastocelično levkemijo s kladribinom = Follow-up of patients with hairy cell leukemia after treatment with cladribine
    Černelč, Peter
    Background. The long-term outcome in 16 patients with hairy cell leukemia (HCL) treated with cladribine between 1995 and 2003 is reported. Patients and methods. Cladribine was administered to 13 ... patients in a dose 0.1 mg/kg/day for 7 days, and the same daily dose was applied once a week for 6 weeks in 3 patients. Their mean age was 57 years (range 32-67) and the male to female ratio 8:1. Four patients had also received a prior therapy with interferon andone was splenectomised. Results. Complete remission (CR) was achieved in 12(75%) patients and partial remission (PR) in 4 (25%) of cases. With a followup of 9 years in 12 patients CR lasted between 18 and 88 months (mean 68), 3 (25%) of them relapsed after 54-80 months (mean 71) while 4 patients with PR progressed after 40 to 76 months (mean 63). Six patients had an infection prior to or during the treatnaent. Conciusions. In HCL patients cladribine treatment yields high percentage of CR and durable response, tolerable toxicity and prolonged survival.
    Vir: Številka ob 2. kongresu hematologov in transfuziologov Slovenije z mednarodno udeležbo (str. I-35-I-37)
    Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasle
    Leto - 2004
    Jezik - slovenski
    COBISS.SI-ID - 17679321

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