VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Rekombinantni faktor VIIa - nova možnost obvladovanja neobvladljive krvavitve pri kirurških bolnikih, poškodovancih in drugih motnjah hemostaze = Recombinant factor VIIa - new treatment option for control of intractable bleeding in surgical and trauma patients and in other haemostasis disorders
    Zver, Samo, 1966- ; Andoljšek, Dušan
    Background. Recombinant factor Vlla (rFVIla), which is currently registered only for the treatment of haemophilia A and B patients with inhibitors, is seen increasingly as a possible universal ... haemostatic agent in untractable bleedings. One possible mechanism for the efficacy rFVIla may be a consequenceof it's from the tissue factor (TF) and from the level of disfunction in haemostatic system independant activity, which generates "thrombin burst" formation. It seems that rFVlla remains active only at the site of tissue injury/bleeding. Conclusions. There are two components of bleeding in surgery and trauma patients. One is bleeding from large calibre arteries and veins which requires surgical intervention. The other, which goesalong with the first one, is coagulopathic bleeding. The latter is a consequence of consumptional and dilutional coagulopathy, hypothermia, multitransfusion syndrom and metabolic disbalances in patients. rFVlla effectscoagulopathic component of the bleeding. For effective treatment with rFVIIa in such patients, replacement therapy with erythrocytes, platelets and fresh frozen plasma is mandatory and requires a haematologist assistance in the treatment strategy. Most reported cases of effective rFVlla usage are fromthe field of traumatology. Until now, there have been no universal recommendations when to start treatment with rFVlla in a bleeding trauma patient. Most experience with rFVlla are from Israel and their recommendationsare perhaps the most valuable ones. rFVlla was used several times during intra-operative and post-operative bleeding episodes. There are reports of clinical studies and usage in patients with/after prostate surgery,cardiovascular operations and liver transplants. There are data about effective rFVlla usage in neurology and neurosurgery patients (intracranial haemorrhages), obstetrics and gynecology field. (Abstract truncated at 2000 characters).
    Vir: Številka ob 2. kongresu hematologov in transfuziologov Slovenije z mednarodno udeležbo (str. I-115-I-121)
    Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasle
    Leto - 2004
    Jezik - slovenski
    COBISS.SI-ID - 17682649

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    Digitalna knjižnica Slovenije - dLib.si

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