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  • Profilaktični ukrepi proti okužbi z virusom hepatitisa C in HIV pri dojenčkih = Prophylactic measures against infection with hepatitis C virus and HIV in infants
    Lešničar, Gorazd
    Background. The World Health Organization estimates that every year more then 500,000 infants get infected with human immunodeficiency virus (HIV) and 10,000 - 60, 000 with hepatitis C virus (HCV) ... worldwide. Rapid and early diagnosis of HCV and HIV infection in exposed infants is rendered difficult because of transplacental passage of maternal IgG antibodies to the virus thatare present in infants up to 28 months of age. Mother-to-infant transmission of HCV is comparatively uncommon. Further- more, chronic hepatitis C does not appear to worsen the outcome of pregnancy or predispose fetal abnormalities. The rate of mother-to-infant transmission is 4 to 7% per pregnancy in women with HCV viremia. Perinatal infection with HCV is usually asymptoynatic. Concomitant infection in pregnant women with HIV increases the rate of transmission of HCV infection 4 to 5 fold. Cesarean section is not recommended and current available medications against HCV infection are contraindicated because of fetal toxicity. Breastfeeding poses no relevant risk of HCV transmission. Conclusions. Perinatal transmission of HIV from mother to child accounts to 5 to 20% of acquired HIV infections worldwide. It is by far the major source of infection and represents more that 90% of all infections in children. Transmission of HIV occurs either before birth, duringdelivevy or through breastfeeding. Recently, zidovudine and some other antiretrovirals administered during pregnancy; at delivery, and in the first 6weeks of life to the infant have reduced transmission by more than two thirds(from. 25 to less than 5%). The experts have also recommended elective cesarean section and dissuaded HIV positive mothers from breastfeeding.. Experts must also test strategies to further decrease the risk for perinatal HCV and HIV infection. Significant progress in the area of new safe and effective vaccines is eagerly expected.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 73, št. 4, april 2004, str. 231-234)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - slovenski
    COBISS.SI-ID - 17859033

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    Digitalna knjižnica Slovenije - dLib.si

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