VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Stereology and morphometry of steatosis in human alcoholic (ALD) and non-alcoholic liver disease (NALD)
    Zaitoun, Abl Al Muti ; Al Mardini, Hanan ; O Record, Christopher
    Steatosis is one of the main features of alcoholic liver disease (ALD) and maybe seen in some patients with non acoholic liver disease (NALD). In this study we have quantitatively assessed steatosis ... in relation to histopathological and clinical categories of ALD and NALD by stereological and morphometric techniques. Haematoxylin and eosin (H&E) stained sections from ninety-two needle liver biopsies were analysed using the Prodit 5.2 system. All biopsies were categorised into five histopathological groups: normal, pure steatosis and parenchyma were assessed by stereological method. The mean diameter, area and area ratio of fat globules in zone 1 and zone 3 were determined by morhometric analysis. Stereological analysis has shown significant variation in the area fraction of fat in different histopathological categories reaching a maximum value of 54% of liver cell parenchyma. Significant differences in the areas of steatosis were observed between the clinical groups (ie ALD and NALD). Morphometric analysis showed significant differences in diameter of fat globules between zone 1 and zone 3 in the two major clinical categories. In alcoholic liver disease fat globules are mainly large and pericentral in location whereas in the non alcoholic group the fat globules are smaller and periportal in location. It can be concluded from this study that quantitative analyses are useful techniques to differentiate between ALD and some sub-clinical categories of NALD. Stereologyhas the advantages of assessing steatosis in the entire liver biopsy specimen while morphometry is very useful for assessing steatosis in relation to topography
    Vir: Acta stereologica. - ISSN 0351-580X (Vol. 17, no. 1, 1998, str. 49-58)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 1835290

vir: Acta stereologica. - ISSN 0351-580X (Vol. 17, no. 1, 1998, str. 49-58)
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