VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Characterizing the heterogeneity of membrane liquid-ordered domains
    Sarkar, Tanmoy ; Farago, Oded
    We use a lattice model of a ternary mixture containing saturated and unsaturated lipids with cholesterol (Chol), to study the structural properties characterizing the coexistence between the ... liquid-disordered and liquid-ordered phases. Depending on the affinity of the saturated and unsaturated lipids, the system may exhibit macroscopic (thermodynamic) liquid–liquid phase separation or be divided into small-size liquid-ordered domains surrounded by a liquid-disordered matrix. In both cases, it is found that the nanoscale structure of the liquid-ordered regions is heterogeneous, and that they are partitioned into Chol-rich sub-domains and Chol-free, gel-like, nano-clusters. This emerges as a characteristic feature of the liquid-ordered state, which helps distinguishing between liquid-ordered domains in a two-phase mixture, and similar-looking domains in a one-phase mixture that are rich in saturated lipids and Chol, but are merely thermal density fluctuations. The nano-structure heterogeneity of the liquid-ordered phase can be detected by suitable experimental spectroscopic methods and is observed also in atomistic computer simulations.
    Vir: The European physical journal. E, Soft matter. - ISSN 1292-8941 (Vol. 46, 2023, article number 99, str. 1-7)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 184994307

    Povezava(-e):

    https://link.springer.com/article/10.1140/epje/s10189-023-00359-7
    DOI

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