VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Proliferative processes, cell cycle deregulation and apoptosis in viral hepatitis
    Cör, Andrej ...
    Hepatitis B virus (HBV) and hepatitis C virus (HCV) are typical non-cytopatic viruses that can induce tissue damage of variable severity by stimulating a protective immune response that can ... simultaneously cause damage and protection, by eliminating the intracellular virus through the destruction of virus infected cells. In hepatitis, virus infection apoptosis of the hepatocytes represents a host defence mechanism against viral infections in which an infected cell prevents viral replication and spread by dying. HBV andHCV replication is cell cycle dependent, supporting the concept of reduced virus replication in proliferative hepatocytes and viral elimination during cell regeneration. Increased hepatocyte proliferative activity is a well-established risk factor for cancer development. Among other environmentalfactors, hepatitis viruses should be listed in the etiology of hepatocellular carcinoma (HCC). Direct integration of HBV viral sequences intothe host genome increases genomic instability, which does not occur in HCVinfection. However, viral proteins may directly play a significant role in increased hepatocyte proliferation and induction of carcinogenesis by both viruses.
    Vir: Viral hepatitis : proceedings (Str. 87-92)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 18616281

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